Aldactone, ingredient spironolactone, is a diuretic or "water pill". It reduces the amount of water and sodium retained by the body. It is used to lower blood pressure, treat fluid retention (edema) and raise low potassium levels. Children Initially 3.3mg/kg per day in single or divided doses. Contraindications Hyperkalemia. Renal impairment. Precautions Hepatic cirrhosis. Hyponatremia. Surgery. Monitor electrolytes. Pregnancy. Nursing mothers: Not recommended. Interactions Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, NSAIDs. Hypokalemia with corticosteroids, ACTH. Antagonized by NSAIDs. Potentiates ganglionic blockers, alcohol, barbiturates, narcotics, skeletal muscle relaxants. Digitalis toxicity. Adverse Reactions Hyperkalemia, hyponatremia, gynecomastia, GI disturbances, drowsiness, headache, rash, confusion, drug fever, ataxia, impotence, hirsutism, voice deepening, menstrual changes, gastric ulcers, agranulocytosis.